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本文应用放射性同位素示踪法,对LCR种小鼠静注~(14)C-柚皮果胶进行了药物动力学、组织分布、排泄和药物代谢的研究,并与~(14)C-右旋糖酐做了对比观察。血浆药物浓度的消除属于一级动力学的动态变化,符合开放形二室模型。其分布相半衰期较短为9分钟,排除相半衰期大约为3小时。静脉注射后30分钟内肾脏的药物浓度较高,而给药1小时后肝脏药物浓度较高。静注后8小时内从尿的排出量为给药量的78％,给药后72小时尿和粪的总排出量为94.3％。应用放射性纸层分析法,显示肝和尿中放射性物质的性质约有82％是原形药物。
In this paper, the pharmacokinetics, tissue distribution, excretion and drug metabolism of intravenous ~ (14) C-pomelo peel pectin in LCR mice were studied by radioisotope tracer method and compared with ~ (14) C-dextran Made a comparative observation. The elimination of plasma drug concentration is a dynamic change in the first order, in line with the open two-compartment model. Its distribution phase half-life of shorter 9 minutes, excluding phase half-life of about 3 hours. Within 30 minutes after intravenous injection, the drug concentration in the kidney is higher, and the drug concentration in the liver is higher after 1 hour of administration. The amount of urine excreted from the urine was 78% of the administered dose within 8 hours after intravenous injection, and the total amount of excreted urine and excreted 72 hours after the administration was 94.3%. Using radioactive paper layer analysis, about 82% of the properties of radioactive material in liver and urine are prototype drugs.