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系统性红斑狼疮(SLE),是具有代表性的全身性炎症性自身免疫性疾患之一,其特征常伴有抗DNA等多种自身抗体阳性反应。这些自身抗体中一部分属Ⅱ型(细胞损伤型;血细胞减少等)或Ⅲ型变态反应型(免疫复合物型;狼疮肾炎;血管炎等),机制与SLE的临床症状出现有关。 1983年发现SLE患者中存在抗磷脂抗体(an-tiphospholipid antibodes;apl)而引起人们的关注,现已证实,存在aPL的SLE患者与一般的SLE患者的症
Systemic lupus erythematosus (SLE) is one of the most common systemic inflammatory autoimmune diseases. Its characteristics are often associated with anti-DNA and other autoantibodies. Some of these autoantibodies are related to the appearance of clinical symptoms of SLE, such as type II (cell injury type; cytopenias, etc.) or type III allergy (immune complex type; lupus nephritis; vasculitis, etc.) The discovery of an-tiphospholipid antibodes (apl) in SLE patients in 1983 has attracted the attention of people and it has been demonstrated that patients with SLE in aPL and patients with SLE generally have symptoms