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目的探讨黄藤素胶囊联合抗生素+雌孕激素治疗子宫内膜炎的临床应用价值。方法将2014年11月—2015年11月收治的子宫内膜炎患者228例采用随机数字法分为2组,每组114例。对照组给予抗生素+雌孕激素,观察组在此基础上加用黄藤素胶囊。观察2组临床表现、阴道B超、月经情况、血清炎症因子(TNF-α、1L-1β)及临床疗效。结果治疗后,观察组分泌物增多患者比例(1.8%)、下腹坠痛患者比例(3.5%)、炎症患者比例(3.5%)均显著低于对照组(15.8%、14.0%、15.8%),均P<0.05。观察组月经周期正常患者比例(94.7%)显著高于对照组(70.2%),P<0.05;治疗后,观察组阴道不规则出血患者比例(3.5%)、月经量异常患者比例(7.0%)显著低于对照组(14.0%、29.8%),P<0.05。治疗后,2组TNF-α、1L-1β水平显著降低(P<0.05),且观察组TNF-α、1L-1β水平显著低于对照组(P<0.05)。治疗后,观察组总有效率(93.0%)显著高于对照组(77.2%),U=2.532,P<0.05。2组均未出现严重不良反应。结论黄藤素胶囊联合抗生素+雌孕激素可有效改善患者临床症状、月经情况及炎症因子水平,治疗效果满意。
Objective To investigate the clinical value of combination of antibiotics and estrogen and progesterone in treatment of endometritis. Methods A total of 228 patients with endometritis who were treated from November 2014 to November 2015 were randomly divided into 2 groups (114 in each group). The control group was given antibiotics plus estrogen and progesterone. The observation group was added with statin capsules on the basis of this. The clinical manifestations, vaginal ultrasonography, menstrual status, serum inflammatory cytokines (TNF-α, 1L-1β) in 2 groups were observed and their clinical effects were observed. Results After treatment, the proportion of excreted patients in observation group (1.8%), lower abdominal pain patients (3.5%) and inflammatory patients (3.5%) were significantly lower than those in control group (15.8%, 14.0%, 15.8% All P <0.05. In the observation group, the proportion of normal menstrual cycle patients (94.7%) was significantly higher than that of the control group (70.2%) (P <0.05); after treatment, the proportion of patients with irregular vaginal bleeding in the observation group was 3.5% Significantly lower than the control group (14.0%, 29.8%), P <0.05. After treatment, the levels of TNF-α and 1L-1β in the two groups were significantly decreased (P <0.05), and the levels of TNF-α and 1L-1β in the observation group were significantly lower than those in the control group (P <0.05). After treatment, the total effective rate (93.0%) in the observation group was significantly higher than that in the control group (77.2%), U = 2.532, no significant adverse reactions in the P <0.05.2 group. Conclusion Combination with antibiotics and progesterone can significantly improve the clinical symptoms, menstruation and inflammatory cytokines levels, and the treatment effect is satisfactory.