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目的：探讨雌二醇受体（ Ｅ Ｒ） 数量与绝经后Ⅱ型糖尿病的关系。方法：选测绝经后Ⅱ型糖尿病患者４２ 例和６０ 例正常妇女（ 绝经前后各３０ 例） 。采用放射配体法检测外周血白细胞 Ｅ Ｒ 含量；采用放射免疫法检测血浆雌二醇（ Ｅ２） 浓度。结果：绝经后Ⅱ型糖尿病患者组白细胞 Ｅ Ｒ 及血浆 Ｅ２ 显著低于正常绝经前组（ Ｐ＜ ０ ．０１） ，且较正常绝经后组也明显下降（ Ｐ＜ ０ ．０１） 。结论：绝经后Ⅱ型糖尿病的发病可能与雌二醇及 Ｅ Ｒ 的降低有关。
Objective: To investigate the relationship between the number of estradiol receptors (E R) and type Ⅱ diabetes mellitus after menopause. Methods: 42 postmenopausal women with type 2 diabetes mellitus and 60 normal women (30 before and after menopause) were selected. Radioimmunoassay was used to detect the content of E2 in peripheral blood leukocytes. Results: The levels of E R and plasma E2 in patients with postmenopausal type Ⅱ diabetes mellitus were significantly lower than those in normal premenopausal women (P <0.01) and significantly lower than those in normal menopausal women (P <0.01). Conclusion: The incidence of postmenopausal type 2 diabetes may be related to the decrease of estradiol and E R.