Lack of an Additive Effect between the Deletions of Klf5 and Nkx3-1 in Mouse Prostatic Tumorigenesis

• 作 者: Changsheng Xing Xiaoying Fu Xiaodong Sun Jin-Tang Dong
• 机 构: Department of Genetics and Cell Biology,College of Life Sciences,Nankai University,Department of Hem
• 出 处: Journal of Genetics and Genomics
• 发表日期: 2013年06期
• 关键词: deletion chromosomal alterations Mouse alone alleles progression suppressor glan

Prostate cancer is one of the most common malignancies.The development and progression of prostate cancer are driven by a series of genetic and epigenetic events including gene amplification that activates oncogenes and chromosomal deletion that inactivates tumor suppressor genes.Whereas gene amplification occurs in human prostate cancer,gene deletion is more common,

Prostate cancer is one of the most common malignancies. The development and progression of prostate cancer are driven by a series of genetic and epigenetic events including gene amplification that activates oncogenes and chromosomal deletion that inactivates tumor suppressor genes. WHEREAS gene amplification occurs in human prostate cancer , gene deletion is more common,