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本文测定了3种疾病(肺心病、肺部感染症、支气管哮喘)患者血浆β-葡萄糖醛酸苷酶(β-g)α_1抗胰蛋白酶(α_1-AT)活性和纤维结合蛋白(Fn)含量。结果发现:肺心病组和肺部感染症组的β-g 和α_1-AT 显著高于正常对照组,Fn 显著低于正常对照组;肺心病急性发作期组β-g 和α_1-AT 明显高于缓解期组,Fn 明显低于缓解期组。其中尤以肺心病临终时的 Fn 降低更甚;肺心病组与感染症组间无显著差异。这说明感染在肺心病发病过程中起着重要作用;β-g、α_1-AT 和 Fn 对判断肺心病病情、预后有重要作用。
In this study, we measured the plasma levels of α-1-AT and β-glucuronidase (α_1-AT) and fibronectin (Fn) in 3 patients with pulmonary heart disease, pulmonary infection and bronchial asthma . The results showed that β-g and α_1-AT in pulmonary heart disease group and pulmonary infection group were significantly higher than those in normal control group, and Fn was significantly lower than that in normal control group. Β-g and α 1 -AT were significantly higher in acute episode of pulmonary heart disease In the remission group, Fn was significantly lower than that in the remission group. Especially in the end of pulmonary heart disease Fn more worse; pulmonary heart disease group and no significant difference between the infection group. This shows that infection plays an important role in the pathogenesis of pulmonary heart disease; β-g, α_1-AT and Fn play an important role in judging the status and prognosis of pulmonary heart disease.