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１８只兔眼玻璃体腔内注射自体血浆０．２ｍｌ制成的玻璃体渗出模型，随机接受玻璃体内注射组织型纤溶酶原激活酶（ｔ－ｐＡ）或生理盐水，其中１０眼玻璃体内注入ｔ－ＰＡｌ２．５μｇ，结果６眼的纤维蛋白在６ｈ内清除，另４眼在ｌｄ内彻底清除。注入生理盐水的７眼需７ｄ才完全清除。两组从时间上比较，差别有显著性（Ｐ＜０．０５）．经裂隙灯、ＥＲＧ、光镜及电镜检查未见毒性作用。另１只注入１００μｇｔ－ＰＡ的兔眼虽然６ｈ内见纤维蛋白凝块溶解，但眼底镜和光镜下已显示视网膜的毒性变化。
Eighteen rabbit eyes were intravitreally injected with autologous plasma 0.2ml vitreous exudation model, and were randomly received intravitreal injection of tissue-type plasminogen activator (t-pA) or saline, of which 10 were intravitreally injected with t -PAl2.5μg, the results of 6 eyes of fibrin cleared within 6h, the other 4 were completely cleared within ld. 7 injection of saline need to be completely removed 7d. There was a significant difference between the two groups in time (P <0.05). The slit lamp, ERG, light and electron microscopy showed no toxic effects. Another injection of 100μgt-PA rabbit eye Although fibrin clot dissolved within 6h, but under the fundus and light microscope retinal toxicity changes have been shown.