论文部分内容阅读
目的了解天津市儿童水痘疫苗初免后的抗体水平、免疫效果和免疫持久性,为制定免疫策略提供参考依据。方法采集接种过1剂次水痘疫苗的儿童静脉血257份,采用酶联免疫吸附试验(ELISA)测定水痘Ig G抗体。结果257名儿童中水痘抗体阳性152人,阳性率59.14%,抗体平均滴度439 m IU/ml。不同年龄组儿童抗体平均滴度差异有统计学意义(F=2.547,P<0.05),6~10岁组平均滴度最低。抗体平均滴度呈现随接种年限延长而明显下降的趋势,不同接种年限抗体平均滴度差异有统计学意义(F=5.253,P<0.05),接种后1~年的儿童抗体平均滴度显著高于接种后5~年的滴度(t=3.18,P<0.05)。结论建议儿童在首剂接种水痘疫苗后加强1剂,尤其在上小学前完成2剂次接种,以提高疫苗的免疫效果。
Objective To understand the antibody level, immune effect and immune persistence of children’s chickenpox vaccine after initial immunization in Tianjin, so as to provide a reference for the development of immunization strategies. Methods A total of 257 venous blood samples were collected from children inoculated with one dose of varicella vaccine. The varicella Ig G antibody was detected by enzyme-linked immunosorbent assay (ELISA). Results Among the 257 children, 152 were positive for varicella, the positive rate was 59.14%, and the average antibody titer was 439 m IU / ml. The average titer of antibody in children of different age groups was significantly different (F = 2.547, P <0.05), and the average titer in 6-10 years old group was the lowest. The average titer of antibody showed a trend of decreasing with the extension of inoculation years. The average titer of antibody in different inoculation years was significantly different (F = 5.253, P <0.05), and the average titer of antibody in children 1 ~ The titers of 5 years after inoculation (t = 3.18, P <0.05). Conclusion It is suggested that children should be given one dose after the first dose of varicella vaccine. In particular, two doses should be given before the elementary school so as to improve the immunization effect.