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1976年Lockwod等首先把血浆置换用于肾脏病治疗。起初用于治疗各种急进性肾炎,现在亦用于治疗其它类型的肾脏病.包括系统性红斑狼疮、IgA肾病、局灶性肾小球硬化及膜增殖性肾炎。关于血浆置换的安全性和疗效尚缺乏大组病例的对照研究。尽管肾小球疾病的预后变幻莫测,某些肾病不可能用血浆置换来治疗。但是,新月体肾炎由于病情危重且常常不可逆,因此,人们对运用血浆置换治疗此病已进行了大量研究。抗GBM抗体介导的新月体性肾炎新月体肾炎发病机理不同,有些病例表现为广
In 1976, Lockwod et al first used plasma exchange for the treatment of kidney disease. Initially used to treat various forms of AGN, it is also currently used to treat other types of kidney disease including systemic lupus erythematosus, IgA nephropathy, focal glomerulosclerosis, and proliferative glomerulonephritis. On the safety and efficacy of plasma exchange is still a large group of cases of controlled study. Although the prognosis of glomerular diseases is unpredictable, some nephropathy can not be treated with plasma exchange. However, crescentic glomerulonephritis due to critical condition and often irreversible, therefore, there has been a lot of research on the use of plasma exchange to treat the disease. Anti-GBM antibody-mediated crescentic nephritis Crescent body nephritis pathogenesis is different, in some cases showed wide