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目的 :分析SPARC表达水平与乳腺癌的发生、发展、侵袭和转移的关系。方法 :以2007年6月~2014年3月在我院接受乳腺手术治疗的137例女性为观察对象,根据其检查结果,乳腺癌者65例,乳腺良性病变者72例。观察两组乳腺SPARC表达水平,比较不同临床病理特征的乳腺癌患者SPARC表达情况的差异,分析SPARC表达水平与患者预后的关系。结果 :两组患者的SPARC表达情况存在显著差异:SPARC阳性表达率由高到低分别为乳腺癌组、良性病变组,差异具有统计学意义;分化程度低、出现淋巴结转移、浸润深度为T3+T4、TNM分期为Ⅲ+Ⅳ期的乳腺癌患者其SPARC阳性表达率较高,而不同年龄、月经状况的乳腺癌患者SPARC阳性表达率无明显差别;恶化组SPARC阳性表达率明显高于好转组,差异具有统计学意义。结论 :SPARC表达水平与乳腺癌的发生、发展、侵袭和转移均密切相关,且预后越差的乳腺癌患者SPARC阳性表达率越高。
Objective: To analyze the relationship between the expression level of SPARC and the occurrence, development, invasion and metastasis of breast cancer. Methods: A total of 137 women undergoing breast surgery in our hospital from June 2007 to March 2014 were enrolled in the study. According to the results of the examination, 65 breast cancer patients and 72 benign breast lesions were observed. The SPARC expression level in the two groups was observed. The differences of SPARC expression in breast cancer patients with different clinicopathological features were compared. The relationship between SPARC expression level and prognosis was analyzed. Results: There was significant difference in the expression of SPARC between the two groups. The expression of SPARC in high and low grade were respectively breast cancer group and benign lesion group, the difference was statistically significant; the differentiation degree was low, lymph node metastasis was found, the infiltration depth was T3 + T4, SPM positive expression rate of breast cancer patients with TNM stage Ⅲ + Ⅳ was higher, while SPARC positive expression rate of breast cancer patients with different age and menstrual status had no significant difference. The SPARC positive expression rate of malignant group was significantly higher than that of remission group , The difference was statistically significant. Conclusion: The expression level of SPARC is closely related to the occurrence, development, invasion and metastasis of breast cancer, and the higher the expression of SPARC in breast cancer patients with worse prognosis.