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目的分析纤维蛋白原(FIB)、活化部分凝血活酶时间(APTT)、凝血酶原时间(PT)、凝血酶时间(TT)、D-二聚体的检测对肝硬化患者的临床意义。方法 41例肝硬化患者作为观察组,选取同期43例进行健康体检的志愿者作为对照组,对比两组患者的FIB、APTT、PT、TT及D-二聚体水平。结果对照组FIB为(3.02±0.06)g/L、APTT为(26.66±2.34)s、PT为(12.11±1.02)s、TT为(12.25±2.06)s及D-二聚体为(0.20±0.03)mg/L,观察组FIB为(1.82±0.04)g/L、APTT为(37.06±3.41)s、PT为(19.46±1.12)s、TT为(18.26±1.98)s及D-二聚体为(0.71±0.20)mg/L,观察组的FIB水平低于对照组,APTT、PT、TT、D-二聚体水平高于对照组,差异具有统计学意义(P<0.05)。结论肝硬化患者纤溶机制和凝血系统存在显著异常,FIB水平表现为降低,APTT、PT、TT、D-二聚体水平表现为增高,联合检测FIB、APTT、PT、TT及D-二聚体水平能反映肝脏损害严重程度,在肝硬化的临床诊断和干预中具有重要作用。
Objective To analyze the clinical significance of fibrinogen (FIB), activated partial thromboplastin time (APTT), prothrombin time (PT), thrombin time (TT) and D-dimer in patients with liver cirrhosis. Methods Forty-one patients with cirrhosis were selected as observation group. Forty-three healthy volunteers were selected as control group to compare the levels of FIB, APTT, PT, TT and D-dimer in the two groups. Results The FIB of the control group was (3.02 ± 0.06) g / L, the APTT was (26.66 ± 2.34) s, the PT was (12.11 ± 1.02) s, the TT was (12.25 ± 2.06) s and the D-dimer was 0.03) mg / L, FIB in observation group was (1.82 ± 0.04) g / L, APTT was (37.06 ± 3.41) s, PT was (19.46 ± 1.12) s, TT was (18.26 ± 1.98) The body weight was (0.71 ± 0.20) mg / L. The FIB level in the observation group was lower than that in the control group. The levels of APTT, PT, TT and D-dimer were higher in the observation group than in the control group (P <0.05). Conclusions The fibrinolytic mechanism and coagulation system of patients with cirrhosis are abnormal. The FIB level is decreased and the levels of APTT, PT, TT and D-dimer are increased. The combined detection of FIB, APTT, PT, TT and D-dimer The level of body can reflect the severity of liver damage, and plays an important role in the clinical diagnosis and intervention of cirrhosis.