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India,under its breeding blanket R&D program for DEMO,is focusing on the development of two tritium breeding blanket concepts;namely the lead-lithium-cooled ceramic breeder and the helium-cooled ceramic breeder (HCCB).The study presented in this paper focuses on the neutronic design analysis and optimization from the tritium breeding perspective of the HCCB blanket.The Indian concept has an edge-on configuration and is one of the variants of the helium-cooled solid breeder blanket concepts proposed by several partner countries in ITER.The Indian HCCB blanket having lithium titanate (Li2TiO3) as the tritium breeder and beryllium (Be) as the neutron multiplier with reduced-activation ferritic/martensitic steel structure aims at utilizing the low-energy neutrons at the rear part of the blanket.The aim of the optimization study is to minimize the radial blanket thickness while ensuring tritium self-sufficiency and provide data for further neutronic design and thermal-hydraulic layout of the HCCB blanket.It is found that inboard and outboard blanket thicknesses of 40 cm and 60 cm,respectively,can give a tritium breeding ratio (TBR) ＞ 1.3,with 60％ 6Li enrichment,which is assumed to be sufficient to cover potential tritium losses and associated uncertainties.The results also demonstrated that the Be packing fraction (PF) has a more profound impact on the TBR as compared to 6Li enrichment and the PF of Li2TiO3.