论文部分内容阅读
口服环丙氟哌酸(CPF)的吸收可用零级过程描述,达峰时间为1～2h。进食对吸收无临床意义的影响,而且可能减轻药物引起的轻度胃部不适。口服或静脉给 CPF 后的浓度和剂量呈线性关系,分布容积为1.74～5.0L/kg,反映药物可透入多数组织。生物利用度约为70％。非肾清除约占33％,目前已鉴定出4种代谢物。据报道 CPF 有首过效应,但无重要临床意义。静注后大约15％从粪便回收。非肾性清除包括代谢分解、胆汁分泌及小肠粘膜分泌。肾小球滤过和肾小管分泌约占血清总清除率的66％。末端处置 t_(1/2)为3～4
Oral ciprofloxacin (CPF) absorption can be zero-level process described, the peak time of 1 ~ 2h. Eating has no clinically significant effect on absorption and may reduce mild stomach upset caused by the drug. After oral or intravenous CPF concentration and dose of a linear relationship between the distribution volume of 1.74 ~ 5.0L / kg, reflecting the drug can penetrate most tissues. Bioavailability is about 70%. About 33% of non-renal clearance, has identified four metabolites. It is reported that CPF has the first pass effect, but no important clinical significance. Approximately 15% of intravenous fluids are recovered from the stool. Non-renal clearance includes metabolic breakdown, bile secretion and small intestinal mucosa secretion. Glomerular filtration and tubular secretion accounted for about 66% of the total serum clearance. The end disposal t_ (1/2) is 3 ~ 4