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[目的]观察朝鲜族老年2型糖尿病患者的胰岛素抵抗(IR)及胰岛β细胞功能.[方法]检测61名新诊断的老年2型糖尿病患者、16例糖调节受损及19例糖耐量正常者的临床指标及血脂水平,并进行口服葡萄糖-胰岛素释放试验.计算胰岛素敏感性指数、HOMA-IR、胰岛β细胞功能指数(HOMA-β)及ΔI30/ΔG30.[结果]与糖耐量正常及糖调节受损组相比较,新诊断的2型糖尿病组患者ΔI30/ΔG30差异无统计学意义(P=0.733,P=0.068),HOMA-β差异有统计学意义(P=0.000,P=0.014);与糖耐量正常组相比较,糖尿病组HOMA-IR及胰岛素敏感性指数差异有统计学意义(P=0.001,P=0.000);与糖调节受损组相比较,糖尿病组HOMA-IR及胰岛素敏感性指数差异无统计学意义(P=0.148,P=0.078).[结论]朝鲜族老年2型糖尿病患者的IR在糖调节受损时期就比较明显,胰岛β细胞功能障碍从糖调节受损到2型糖尿病逐渐加重.
[Objective] To observe the insulin resistance (IR) and pancreatic β-cell function in elderly Korean type 2 diabetic patients. [Methods] Sixty-one 61 newly diagnosed elderly patients with type 2 diabetes mellitus, 16 patients with impaired glucose regulation and 19 normal glucose tolerance HOMA-IR, HOMA-β, and ΔI30 / ΔG30 were calculated. [Results] Compared with patients with normal glucose tolerance and normal glucose tolerance, the insulin sensitivity index, HOMA- There was no significant difference in ΔI30 / ΔG30 between the newly diagnosed type 2 diabetic patients and the impaired glucose regulation (P = 0.733, P = 0.068), but there was a significant difference in HOMA-β between the two groups (P = 0.000, P = 0.014 ). Compared with normal glucose tolerance group, the difference of HOMA-IR and insulin sensitivity index in diabetes mellitus group was statistically significant (P = 0.001, P = 0.000). Compared with glucose-regulated impairment group, HOMA-IR and There was no significant difference in insulin sensitivity index (P = 0.148, P = 0.078). [Conclusion] The IR of Korean elderly patients with type 2 diabetes mellitus is more obvious in impaired glucose regulation. Damages to type 2 diabetes gradually increased.