【摘 要】
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Xiexin decoctions (XXDs) display beneficial anti-inflammatory and anti-diabetic effects,which raises interests on this group of formulae for broad clinical appl
【机 构】
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Pharmaceutical Informatics Institute,College of Pharmaceutical Sciences,Zhejiang University,Hangzhou
论文部分内容阅读
Xiexin decoctions (XXDs) display beneficial anti-inflammatory and anti-diabetic effects,which raises interests on this group of formulae for broad clinical applications.However,there was no report about systematic analysis of XXDs to elucidate the constitution of chemical components,which hampers further investigations on the therapeutic values of XXDs.In this work,crude herbs were extracted and prepared to obtain the XXDs for systemic analysis on their chemical compositions,according to the informa-tion described in the ancient Zhang Zhongjing's herbal formulae.LC-MS analysis of five XXDs was carried out to facilitate recogni-tion of the source herbs for compounds in the mixture.A total number of 93 compounds were identified through our methods and their chemical classes encompassed five major groups,including protoberberine alkaloids,flavonoids,stilbenes,anthraquinones and sapon-ins.Our current work provided important information about material basis for pharmacological studies on XXDs and would help shed light on relationships between chemical compositions and therapeutic effects.
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