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目的探讨米索前列醇预防产后出血的效果。方法对2004年2月~2006年2月在我院住院分娩的有产后出血高危因素的100例产妇,随机分为奇数实验组和偶数对照组,各50例。两组年龄、孕周、高危因素经统计学处理差异无统计学意义。实验组胎儿娩出后立即口服和舌下含化米索前列醇600μg,对照组胎儿娩出后立即肌肉注射或宫体注射缩宫素20 IU,产后静脉滴注5%葡萄糖液+缩宫素10 IU。结果实验组产后出血量明显减少(P<0.01),产后出血发生率为0。结论米索前列醇能预防和减少产后出血的发生率。
Objective To investigate the effect of misoprostol on postpartum hemorrhage. Methods From February 2004 to February 2006 in our hospital 100 births with high risk factors for postpartum hemorrhage were randomly divided into odd experimental group and even control group, 50 cases each. Two groups of age, gestational age, risk factors by statistical analysis, no significant difference. Immediately after oral administration and misoprostolization, 600 μg of misoprostol was administered to the fetus of the experimental group, and 20 IU of intrauterine injection of oxytocin and intramuscular injection of oxytocin were administered intramuscularly or intrauterinely. The fetus was infused intravenously with 5% glucose solution and oxytocin 10 IU . Results The amount of postpartum hemorrhage was significantly decreased in experimental group (P <0.01), and the incidence of postpartum hemorrhage was 0. Conclusion Misoprostol can prevent and reduce the incidence of postpartum hemorrhage.