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目的临床评估单纯阿托伐他汀治疗和阿托伐他汀联合普罗布考治疗对脑脑梗死动脉粥样硬化斑块患者的疗效差异,为颈动脉粥样硬化斑块患者的临床用药提供新的指导。方法选择我院诊断治疗的颈动脉粥样硬化引发脑梗死患者128例,随机分为观察组和对照组,对照组给予阿托伐他汀治疗,观察组在对照组基础上联合使用普罗布考治疗,观察比较两组治疗效果。结果观察组患者治疗后血脂改善情况、颈动脉粥样硬化斑块厚度和面积改善程度均明显优于对照组(P<0.05);不良反应发生情况中两组患者比较差异无统计学意义(P>0.05)。结论普罗布考联合常规剂量阿托伐他汀治疗组可以有效地降低颈动脉粥样硬化患者的血清LDL-C水平,联合用药能够明显逆转颈动脉粥样硬化斑块,降低血脂水平。阿托伐他汀常规剂量治疗组逆转冠状动脉粥样斑块进展的程度不明显。
Objective To evaluate the clinical effects of atorvastatin alone and atorvastatin combined with probucol on patients with atherosclerotic plaque in patients with cerebral infarction and to provide new guidelines for the clinical use of patients with carotid atherosclerotic plaques . Methods One hundred and eighty-eight patients with carotid atherosclerosis-induced cerebral infarction who were diagnosed and treated in our hospital were randomly divided into observation group and control group, and control group were given atorvastatin. The observation group was treated with probucol on the basis of control group , Observed and compared the treatment effect of two groups. Results The improvement of blood lipids, carotid atherosclerosis plaque thickness and area improvement in observation group were significantly better than those in control group (P <0.05). There was no significant difference between the two groups in the incidence of adverse reactions (P > 0.05). Conclusions Probucol combined with conventional dose of atorvastatin can effectively reduce the level of serum LDL-C in patients with carotid atherosclerosis. Combined treatment can significantly reverse the carotid atherosclerotic plaque and lower the level of serum lipids. Atorvastatin conventional dose treatment group to reverse the extent of coronary atherosclerotic plaque was not obvious.