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目的:观察α-2b干扰素在LEEP术前、术后用药的治疗效果。方法:将210例中、重度宫颈炎患者随机分为观察组Ⅰ、观察组Ⅱ及对照组。观察组Ⅰ于LEEP术后应用α-2b干扰素治疗一个疗程;观察组Ⅱ于LEEP术前用α-2b干扰素治疗一个疗程;对照组单行LEEP术。观察3组术中、术后脱痂出血量,阴道流液量,流液持续时间,术后感染率及伤口愈合情况。结果:观察组Ⅰ、观察组Ⅱ术后脱痂出血量,阴道流液量、流液持续时间及感染率均明显低于对照组(P<0.05),术后1、2月宫颈痊愈率明显高于对照组(P<0.05),且观察组Ⅰ的治疗效果明显优于观察组Ⅱ。结论:α-2b干扰素与LEEP术联合应于中、重度宫颈炎的治疗可明显降低了LEEP术后感染率,且促进伤口早期愈合,用药方法以LEEP术后应用α-2b干扰素为宜。
Objective: To observe the therapeutic effect of interferon α-2b before and after LEEP. Methods: 210 cases of moderate and severe cervicitis patients were randomly divided into observation group Ⅰ, observation group Ⅱ and control group. Observation group Ⅰ in the LEEP after the application of α-2b interferon for a course of treatment; observation group Ⅱ before LEEP with α-2b interferon for a course of treatment; control group single-line LEEP surgery. Three groups were observed intraoperative, postoperative off scab bleeding, vaginal fluid flow, fluid duration, postoperative infection rate and wound healing. Results: The bleeding volume, vaginal fluid volume, duration of fluid flow and infection rate in observation group Ⅰ and observation group Ⅱ were significantly lower than those in control group (P <0.05). The cure rate of cervix in 1 and 2 months after operation was significantly Higher than that of the control group (P <0.05), and the treatment effect of observation group Ⅰ was obviously better than that of observation group Ⅱ. Conclusions: The combination of interferon alfa-2b and LEEP should be effective in treating moderate and severe cervicitis, which can significantly reduce the infection rate after LEEP and promote early wound healing. The use of interferon α-2b after LEEP is appropriate .