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为探讨喉上皮癌变过程中 Ｐ５３ 蛋白表达水平，采用免疫组化技术检测了１１ 例喉上皮单纯性增生（ Ｓ Ｈ Ｅ）、３２ 例非典型性增生（ Ａ Ｈ Ｅ）及 ４２ 例喉鳞状细胞癌（ Ｌ Ｓ Ｃ Ｃ） Ｐ５３ 蛋白的表达。结果： Ｐ５３ 蛋白阳性表达率在 Ｓ Ｈ Ｅ、 Ａ Ｈ Ｅ 及 Ｌ Ｓ Ｃ Ｃ 中分别为 ０００％ 、３１．２５％ 及 ５２．３８％ ；轻、中、重度 Ａ Ｈ Ｅ 阳性率分别为 ０００％ 、３３．３３％ 及７５％ ；高、中、低分化 Ｌ Ｓ Ｃ Ｃ阳性率分别为６２．５０％ 、７６．９２％ 、１５．３９％ ，其差异有高度显著性（ Ｐ＜ ０．０１）。 Ｐ５３ 蛋白表达与喉癌临床分期、分型、颈淋巴转移、局部复发及预后无相关性。结果提示：喉上皮由正常状态向恶性转化的过程中，存在抑癌基因突变产物 Ｐ５３ 蛋白过度表达，可能与喉癌的发生发展有一定关系。
To investigate the expression of P53 protein during laryngeal carcinogenesis, 11 cases of laryngeal simple hyperplasia (S H E), 32 cases of atypical hyperplasia (A H E) and 42 cases of laryngeal squamous cell Cancer (L S C C) P53 protein expression. Results: The positive rates of P53 protein were 000%, 31.25% and 52.38% in S H E, A H E and L S C C, respectively. The positive rates of mild, moderate and severe A H E were 000%, 33.33% and 75%, respectively. The positive rates of high, moderate, and poorly differentiated L s C C were 62.50%, 76.92% and 15.39%, respectively <0.01). P53 protein expression and laryngeal cancer clinical stage, type, cervical lymph node metastasis, local recurrence and prognosis no correlation. The results suggest that there is overexpression of p53 gene, a product of tumor suppressor gene, in the process of normal to malignant transformation of the laryngeal epithelium, which may be related to the occurrence and development of laryngeal carcinoma.