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某些致病菌如埃希氏大肠杆菌、鼠伤寒杆菌可产生Enterochelin,此物质在体外可激活相应的细菌生长并增加细菌的毒力。近来研究发现在正常人血清中存在对Enterochelin的特异性抗体,此抗体对产生Enterochelin的致病菌具有特异的抑制作用。体外培养证明,上述细菌培养既使在含有加热灭活的正常人血清的培养基中也难以生长,主要因为血清中含有Enterochelin的特异性抗体。据推测这种抗体可与血清中的运铁蛋白作用,阻碍致病菌与铁的同化作用,因此无法合成含铁的细菌,使细菌生长受阻碍。
Some pathogens such as Escherichia coli, Salmonella typhimurium can produce Enterochelin, this substance can activate the corresponding bacterial growth in vitro and increase the virulence of bacteria. Recent studies have found that in normal human serum Enterochelin-specific antibodies exist, this antibody has a specific inhibitory effect on Enterochelin-producing pathogens. In vitro culture demonstrated that the above-mentioned bacterial culture was difficult to grow even in a medium containing heat-inactivated normal human serum, mainly because serum contained Enterochelin-specific antibodies. It is speculated that this antibody can interact with transferrin in serum and hinder the assimilation of pathogenic bacteria and iron, so that it is impossible to synthesize iron-containing bacteria and obstruct the growth of bacteria.