Synthesis of chiral dihydrofuran compounds by thiourea derivatives-catalyzed“interrupted”Feist-B

• 作 者: Hui Chen Sheng Yong Zhang
• 机 构: a,DrugControl
• 出 处: 中国化学快报：英文版
• 发表日期: 2010年2期
• 关键词: 鈥淚n terrupted 鈥 ? Feist-B 茅 n ary (IFB ) 反应 CHIRAL THIOUREA DIHYDROFURAN 'In
• 基金项目: the National Natural Science Foundation of China(Nos.20572131,20372083,20972189,20672141, 30901883)

In this study,six thiourea derivatives of cinchona alkaloids with 9-nat or 9-epi-configuration were synthesized.After characterized the structures,we adopted them to the asymmetric'interrupted'Feist-Benary(IFB) reaction ofα-haloketones with β-dica