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目的:研究三磷酸肌苷焦磷酸酶(ITPA)活性在中国汉族人中的分布.方法:运用HPLC法测定402名健康汉族人红细胞的ITPA活性.结果:不同性别、不同血型汉族人的红细胞ITPA活性均值差异无统计学意义(P＞0.05),其ITPA活性呈双峰分布,活性缺乏率为27.6%.此外发现6例ITPA活性缺乏者,占研究总人数的1.47%.结论:中国汉族人红细胞ITPA活性呈双峰分布.“,”AIM: To study the distribution of in-osine triphosphate pyrophosphatase (ITPA) activity in Han Chinese. METHODS: The erythrocyte ITPA activity was detected in healthy Han Chinese by HPLC assay (n = 402). RESULTS: There was no significant difference in the mean ITPA activity between male and female of Han Chinese or among different blood types(P > 0.05), a bimodal distribution of ITPA activity was found and the frequency of the ITPA deficiency was 27.6% in Han Chinese. Furthermore, 6 cases with ITPA activity deficiency were found, accounting for 1.47 % of total healthy recipients. CONCLUSION: The distribution of erythrocyte ITPA activity shows a bimodal distribution in Han Chinese.