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目的单唾液酸四己糖神经节苷脂(GM1)与复方丹参对极低出生体重儿神经系统预后的影响。方法 108例极低出生体重儿分为两组:在治疗原发病和早产儿各项并发症的基础上,治疗组在生后3天给予GM1(20mg/d)和复方丹参注射液(2ml/d),对照组给予复方丹参注射液(2ml/d),均连用14天为一个疗程。纠正胎龄37周后两组NBNA评分进行比较。结果纠正胎龄足月后治疗组NBNA评分明显高于不用GM1的对照组(P<0.01)。结论 GM1联用复方丹参在改善极低出生体重儿神经系统预后方面有较好的疗效。
Objective To investigate the effect of ganglioside monosialotetrahexosylglucose (GM1) and compound salvia miltiorrhiza on nervous system prognosis of very low birth weight infants. Methods 108 cases of very low birth weight children were divided into two groups: on the basis of the treatment of the primary disease and the complications of prematurity, the treatment group was given GM1 (20mg / d) and compound Danshen injection (2ml / d), the control group given compound Salvia injection (2ml / d), were used for 14 days for a course of treatment. 37 weeks after correction of gestational age NBNA scores were compared. Results Correction of gestational age after treatment NBNA score was significantly higher than the control group without GM1 (P <0.01). Conclusion GM1 combined with Salvia miltiorrhiza in improving the prognosis of very low birth weight children have a better outcome.