Molecular design,synthesis strategies and recent advances of hydrogels for wound dressing applicatio

• 作 者: Dan Zeng Shihong Shen Daidi Fan
• 机 构: Shaanxi Key Laboratory of Degradable Biomedical Materials,Shaanxi R&D Center of Biomaterials and Fer
• 出 处: 中国化学工程学报（英文版）
• 发表日期: 2021年2期
• 关键词: Hydrogels Wound dressing Molecular design Crosslinked networks Biomedical applic

With the changes in the modern disease spectrum,pressure ulcers,diabetic feet,and vascular-derived diseases caused refractory wounds is increasing rapidly.The development of wound dressings has partly improved the effect of wound management.However,traditional wound dressings can only cover the wound and block bacteria,but are generally powerless to recurrent wound infection and tissue healing.There is an urgent need to develop a new type of wound dressing with comprehensive performance to achieve multiple effects such as protecting the wound site from the external environment,absorbing wound exudate,anti-inflammatory,antibacterial,and accelerating wound healing process.Hydrogel wound dressings have the aforementioned characteristics,and can keep the wound in a moist environ-ment because of the high water content,which is an ideal choice for wound treatment.This review intro-duces the wound healing process and the development and performance advantages of hydrogel wound dressings.The choice of different preparation materials gives the particularities of different hydrogel wound dressings.It also systematically explains the main physical and chemical crosslinking methods for hydrogel synthesis.Besides,in-depth discussion of four typical hydrogel wound dressings including double network hydrogels,nanocomposite hydrogels,drug-loaded hydrogels and smart hydrogels fully demonstrates the feasibility of developing hydrogels as wound dressing products and their future devel-opment trends.