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目的:考察不同温度下注射用盐酸博安霉素与0.9%氯化钠注射液配伍的稳定性,为临床合理用药提供依据。方法:采用HPLC法考察配伍液中盐酸博安霉素的含量变化,并观察配伍溶液的外观、pH和紫外吸收图谱的变化。结果:盐酸博安霉素的线性范围为30～100μg·ml~(-1)(r=0.999 9),平均回收率为99.69%,RSD=0.34%(n=9)。在实验的各个温度下,配伍液放置48h,外观、pH及紫外吸收图谱均无明显变化,而博安霉素含量有所降低。结论:博安霉素-0.9%氯化钠配伍液在冰箱内储存24h稳定;夏季、常温使用该药物时,宜现用现配,并于4h内输注完毕。
OBJECTIVE: To investigate the stability of the combination of boanmycin hydrochloride and 0.9% sodium chloride injection at different temperatures to provide the basis for clinical rational drug use. Methods: HPLC method was used to investigate the content of boehmomycin hydrochloride in the compatibility solution. The appearance, pH and UV absorption of the compatibility solution were observed. Results: The linear range of boeamycin hydrochloride was 30 ~ 100μg · ml ~ (-1) (r = 0.999 9). The average recovery was 99.69%, RSD = 0.34% (n = 9). In the experimental temperature, the compatibility solution was placed 48h, appearance, pH and UV absorption spectra were no significant changes, while the decreased content of boeamycin. Conclusion: Bleomycin - 0.9% sodium chloride compatibility liquid stored in the refrigerator 24h stable; summer, when using the drug at room temperature, should now be used with the current, and in 4h infusion completed.