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伏立康唑(voriconazole)是三唑类抗真菌药物,其抗真菌谱广,活性高,胃肠道吸收好。其抗菌机制是抑制真菌细胞色素P450介导的14α-甾醇的去甲基作用,从而抑制真菌麦角甾醇的合成。而麦角甾醇好似真菌浆膜的必要组成部分。这样导致真菌细胞膜合成不足[1]。研究结果显示伏立
Voriconazole is a triazole antifungal agent with broad antifungal spectrum, high activity and good gastrointestinal absorption. Its antibacterial mechanism is to inhibit fungal cytochrome P450-mediated 14α-sterol demethylation, thereby inhibiting the synthesis of fungal ergosterol. And ergosterol is like an essential part of the fungal serosa. This led to the lack of synthesis of fungal cell membrane [1]. The results show that the Volatile