胃癌病人血清3种细胞因子测定及其临床意义探讨

• 作 者: 陈垦 汤斌 许庆文 官成浓 梁坚
• 机 构: 广东医学院附属医院,广东医学院微生物与免疫学教研室,广东医学院附属医院,广东医学院附属医院,广东医学院附属医院
• 出 处: 实用癌症杂志
• 发表日期: 2000年01期
• 关键词: 胃癌 肿瘤坏死因子α 白细胞介素6 白细胞介素8

目的　探讨胃癌病人血清肿瘤坏死因子α（ＴＮＦα） 、白细胞介素６（ＩＬ６） 和白细胞介素８（ＩＬ８） 水平的变化及其临床意义。方法　采用ＥＬＩＳＡ 法测定３５ 例胃癌病人血清ＴＮＦα、ＩＬ６ 和ＩＬ８ 水平，并与胃良性肿瘤组和正常对照组进行比较分析。结果　胃癌病人血清ＴＮＦα、ＩＬ６ 和ＩＬ８ 水平明显增高（ Ｐ＜ ０ ．０１） ，并与临床分期有关（Ｐ ＜ ０ ．０５） ，病灶切除后血清ＴＮＦα、ＩＬ６和ＩＬ８ 水平明显降低（Ｐ＜ ０ ．０５） 。结论　胃癌病人有细胞免疫功能紊乱，血清中ＴＮＦα、ＩＬ６ 和ＩＬ８ 水平的增高可能与疾病的发生、发展有关，血清ＴＮＦα、ＩＬ６ 和ＩＬ８ 可作为胃癌病人病情判断和疗效的观察指标之一。

Objective To investigate the changes and clinical significance of serum tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) and interleukin-8 (IL-8) levels in patients with gastric cancer. Methods The levels of serum TNFα, IL6 and IL8 in 35 patients with gastric cancer were measured by ELISA. The results were compared with those of benign tumors and normal controls. Results The levels of serum TNFα, IL6 and IL8 in patients with gastric cancer were significantly higher (P 0. 01) and correlated with clinical stages (P 0.05). Serum TNFα and IL6 after resection of the lesions. The level of IL-8 was significantly lower (P < 0.05). Conclusions The patients with gastric cancer have disordered cellular immune function. The increase of serum TNFα, IL6 and IL8 levels may be related to the occurrence and development of the disease. Serum TNFα, IL6 and IL8 may be used as gastric cancer patients. One of the observed indicators of disease condition and efficacy.