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目的:研究尿激酶型纤溶酶原激活剂(uPA)及其抑制剂(PAI-1)在舌鳞癌(TSCC)中的表达及其与临床病理参数的关系。方法:应用链霉卵白素-生物素复合体方法检测uPA及PAI-1在74例TSCC组织和15例癌旁正常黏膜中的表达。以SPSS10.0软件包对数据进行统计学处理,Kappa一致性法分析uPA和PAI-1表达的相关性,χ2检验分析两者的表达水平与舌癌临床指标的关系,连续校正法检验两者联合表达与颈淋巴结转移间的关系。结果:TSCC组织中uPA和PAI-1阳性表达率分别为71.6%(53/74)和75.7%(56/74)。uPA的表达水平与临床分期、颈淋巴结转移相关,与肿瘤病理学分级无关;PAI-1与临床分期、颈淋巴结转移相关,与肿瘤病理学分级无关。uPA和PAI-1同时阳性表达组,颈淋巴结转移率显著高于同时阴性表达组(P<0.05)。结论:uPA和PAI-1表达在TSCC中明显升高,并与TSCC的颈淋巴结转移密切相关。
Objective: To investigate the expression of urokinase-type plasminogen activator (uPA) and its inhibitor (PAI-1) in tongue squamous cell carcinoma (TSCC) and its relationship with clinicopathological parameters. Methods: The expression of uPA and PAI-1 in 74 TSCC tissues and 15 normal mucosa tissues was detected by streptavidin-biotin complex method. SPSS10.0 software package for the data were statistically analyzed, Kappa consistency analysis of the correlation between uPA and PAI-1 expression, χ2 test analysis of the relationship between the two indicators and clinical indicators of tongue cancer, continuous calibration test both Relationship between joint expression and cervical lymph node metastasis. Results: The positive rates of uPA and PAI-1 in TSCC were 71.6% (53/74) and 75.7% (56/74), respectively. The expression level of uPA was correlated with clinical stage and cervical lymph node metastasis, but not with tumor pathological grade. PAI-1 was correlated with clinical stage and cervical lymph node metastasis, but not with tumor pathological grade. The positive rates of uPA and PAI-1 expression in cervical lymph node were significantly higher than those in negative expression group (P <0.05). Conclusion: The expressions of uPA and PAI-1 are significantly increased in TSCC and closely related to cervical lymph node metastasis of TSCC.