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目的探讨腺泡细胞癌的临床病理特点、免疫组化表型及诊断与鉴别诊断。方法复习1例腺泡细胞癌的临床资料,行组织学观察和免疫组化分析,并复习相关文献。结果患者女性,42岁。腹部CT发现胰腺占位,肝多发性实性占位,腹腔淋巴结肿大。胰腺肿物位置较深,受周围器官影响,只能行肝肿物穿刺。穿刺组织显示肿瘤细胞呈腺泡状、实性排列,可见坏死。免疫组化:CK7、CK8/18、CK19、α-AAT和α-ACT(+)。结论腺泡细胞癌不仅腺泡分化标记物α-AAT,α-ACT和CK8/18等可以(+),胰腺导管分化标记物CK7和CK19等也可以(+)。
Objective To investigate the clinicopathological features, immunohistochemical phenotypes, diagnosis and differential diagnosis of acinar cell carcinoma. Methods One case of acinar cell carcinoma was reviewed. Histological observation and immunohistochemistry were performed. The related literatures were reviewed. Results Female patient, 42 years old. Abdominal CT found pancreas, multiple solid lesions, abdominal lymph nodes. Deep pancreatic tumor location, affected by the surrounding organs, only the liver tumor puncture. Puncture tissue showed acinar tumor cells, arranged in real, visible necrosis. Immunohistochemistry: CK7, CK8 / 18, CK19, α-AAT and α-ACT (+). Conclusions Acinar cell carcinoma can not only acinar differentiation markers α-AAT, α-ACT and CK8 / 18, but also (+) pancreatic ductal markers CK7 and CK19.