Inhibitary effects of antisense oligonucleotide specific to K-ras point mutation on the target gene

• 出 处: Chinese Medical Journal
• 发表日期: 2007年16期
• 关键词: antisense considerably mutation difficulty survive prognosis operative chemother

The prognosis of pancreatic carcinoma is disappointingdue to the difficulty of early and accurate diagnosis,low operative resection rate,insensitivity to radiationtherapy and chemotherapy.The incidence of pancreaticcarcinoma has increased considerably in the past fewyears,the progress of diagnosis and treatment,however,has not been significantly improved.The overall 5-yearsurvive rate is still as low as 5%-10%,and the improved5 years survive rate is about 20%-40% after successiveWhipple-operation.The early diagnosis is critical to thesuccessful surgical treatment.It depends on theestablishment of the new way for that.

The prognosis of pancreatic carcinoma is disappointingdue to the difficulty of early and accurate diagnosis, low operative resection rate, insensitivity to radiationtherapy and chemotherapy.The incidence of pancreaticcarcinoma has increased considerably in the past fewyears, the progress of diagnosis and treatment, however, has not was significantly improved. The overall 5-yearurvive rate is still as low as 5% -10%, and the improved 5-year survive rate is about 20% -40% after successive Whip-operation. The early diagnosis is critical to the successful surgical treatment. It depends on theestablishment of the new way for that.