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目的探讨大肠癌微血管密度(MVD)及增殖细胞核抗原(PCNA)与手术后有无潜在性肿瘤转移及复发的相关性。方法对55例大肠癌进行术后5a的随访及石蜡标本的S-P免疫组化法染色。结果大肠癌MVD与其分化程度密切相关(P<0.01);与临床病理分期(Dukes’)间差异有显著意义(P<0.05);与有无淋巴结、肝转移密切相关(P<0.05);在术后复发与无复发生存者间差异有非常显著性意义(F<0.01)。增殖活性表达提示,分化愈差,有淋巴结或肝转移时,增殖活性增高,术后复发与无复发生存者之间,增殖活性差异有显著意义(P<0.05)。结论大肠癌MVD及PCNA与肿瘤的浸润、淋巴结及肝转移相关。手术时虽无明显转移,但MVD增高及PCNA活性增强,提示可能有潜在的转移存在。
Objective To investigate the relationship between microvessel density (MVD), proliferating cell nuclear antigen (PCNA) and potential tumor metastasis and recurrence after operation. Methods 55 cases of colorectal cancer after follow-up of 5a and paraffin specimens S-P immunohistochemical staining. Results The MVD in colorectal cancer was closely related to the degree of differentiation (P <0.01), but not to the clinical stage (Dukes’) (P <0.05). It was closely related to the presence or absence of lymph nodes and liver metastasis (P <0.05) The difference between postoperative recurrence and non-recurrence survivors was very significant (F <0.01). Proliferation of active expression suggests that the worse the differentiation, lymph node or liver metastasis, increased proliferative activity, postoperative recurrence and recurrence of survivors, the difference was significant (P <0.05). Conclusion MVD and PCNA in colorectal cancer are related to tumor invasion, lymph node metastasis and liver metastasis. Although there was no obvious metastasis at the time of operation, the increase of MVD and the enhancement of PCNA activity suggested that there might be potential metastasis.