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目的探讨2型糖尿病(T2DM)患者血清脂联素(APN)、肿瘤坏死因子α(TNF-α)水平与颈动脉内膜-中层厚度(IMT)的关系。方法对120例T2DM患者的大血管病变危险因素进行采集,应用B超技术测量其IMT,同时测定空腹血清APN和TNF-α水平,观察IMT增厚组(IMT≥1mm,n=56)与不增厚组(IMT<1mm,n=64)血清APN和TNF-α水平与IMT的关系。结果 T2DM患者IMT增厚组血清TNF-α高于IMT不增厚组(P=0.0018),血清APN低于IMT不增厚组(P=0.0014),相关分析显示,IMT与TNF-α呈正相关(r=0.45,P<0.01),与APN呈负相关(r=-0.51,P<0.01)。结论 T2DM患者IMT增厚与空腹血清APN水平降低、TNF-α水平升高明显相关,提示血清APN和TNF-α水平变化参与颈动脉粥样硬化的发生和发展过程,与颈动脉粥样硬化性狭窄关系密切。
Objective To investigate the relationship between serum adiponectin (APN), tumor necrosis factor-α (TNF-α) and carotid artery intima-media thickness (IMT) in type 2 diabetes mellitus (T2DM) Methods The risk factors of macrovascular complications in 120 patients with T2DM were collected. The IMT was measured by B-ultrasound and the levels of APN and TNF-α in fasting serum were measured. The IMT thickening group (IMT≥1mm, n = 56) Thickening group (IMT <1mm, n = 64) serum levels of APN and TNF-α and IMT relationship. Results The serum levels of TNF-α in IMT thickening group were significantly higher than those in non-IMT thickening group (P = 0.0018), while the serum APN was lower in IMT thickening group (P = 0.0014). Correlation analysis showed that there was a positive correlation between IMT and TNF- (r = 0.45, P <0.01), but negatively correlated with APN (r = -0.51, P <0.01). Conclusions Thickening of IMT in T2DM patients is associated with the decrease of APN and the increase of TNF-α in fasting serum, suggesting that the changes of serum APN and TNF-α are involved in the occurrence and development of carotid atherosclerosis, Close relationship between stenosis.