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目的:探讨胰岛素样生长因子ⅡmRNA结合蛋白3(IMP3)在平滑肌肉瘤及平滑肌瘤中的表达及意义。方法:应用免疫组化SP法观察IMP3在15例平滑肌肉瘤患者中的表达情况及与临床病理特征的关系,同时选取54例平滑肌瘤患者作为对照。结果:IMP3在平滑肌肉瘤患者中的阳性表达率为73.33%(11/15),IMP3在子宫组、中低分化组、肿瘤性坏死组、核分裂计数≥25个/10 HPF组及ki67>20%组的阳性表达率高于子宫外组、高分化组、无肿瘤性坏死组、核分裂<25个/10 HPF组及ki67≤20%、≤10%组(P<0.05);随访病例中,死亡、复发及转移病例(100.00%,4/4)均表达IMP3,明显高于健在且未复发、转移病例(60.00%,6/10),两组比较差异无统计学意义(P>0.05)。在54例平滑肌瘤患者中仅5例(9.26%)弱至中度阳性表达IMP3,IMP3在平滑肌肉瘤与平滑肌瘤中的表达比较差异有统计学意义(P<0.05)。结论:IMP3参与了平滑肌肉瘤的发生并在该肿瘤中高度表达,可作为一个新的与平滑肌瘤鉴别的辅助指标。
Objective: To investigate the expression and significance of insulin-like growth factor Ⅱ-binding protein 3 (IMP3) in leiomyosarcoma and leiomyoma. Methods: Immunohistochemical SP method was used to observe the expression of IMP3 in 15 cases of leiomyosarcoma and its relationship with clinicopathological features. At the same time, 54 cases of leiomyoma were selected as control. Results: The positive expression rate of IMP3 in patients with leiomyosarcoma was 73.33% (11/15). The expression of IMP3 in uterus, moderately poorly differentiated group, neoplastic necrosis group, mitotic count≥25 / 10 HPF group and ki67> 20% The positive expression rate of the group was higher than that of the uterus group, the well-differentiated group, the non-neoplastic group, the mitotic <25/10 HPF group and the ki67≤20%, ≤10% group (P <0.05) (100.00%, 4/4). The expression of IMP3 was significantly higher in patients with recurrence and metastasis (60.00%, 6/10) than in healthy controls without recurrence and metastasis. There was no significant difference between the two groups (P> 0.05). In 54 cases of leiomyoma, only 5 cases (9.26%) had weak to moderate positive expression of IMP3. The expression of IMP3 in leiomyosarcoma and leiomyoma had statistical significance (P <0.05). Conclusion: IMP3 is involved in the pathogenesis of leiomyosarcoma and is highly expressed in this tumor. It may serve as a new adjunct to the identification of leiomyoma.