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目的探讨拉萨、那曲和锦州地区男性青少年血清骨碱性磷酸酶(BAP)、Ⅰ型前胶原羧基端前肽(PICP)和骨钙素(OC)水平特点及其差异,为开展青少年生长发育研究提供依据。方法选取西藏拉萨与那曲地区的12～18岁健康藏族男性青少年共746人,锦州平原地区汉族男性青少年343人,测定身高及血清BAP、PICP和OC的含量。结果拉萨和那曲组血清BAP、PICP和OC平均水平均高于锦州组,且拉萨组与锦州组比较差异均有统计学意义(P值均<0.01);拉萨组3个指标的水平显著高于那曲组(P<0.01或P<0.05)。拉萨组血清BAP、PICP和OC在13～14岁均出现高峰;而那曲组和锦州组其高峰出现的年龄均提前1 a。随年龄增长,3组各生化标志物水平均明显下降(P值均<0.05)。血清BAP、PICP和OC水平均与身高密切相关(r=0.43,0.54,0.41,P值均<0.01)。结论不同海拔地区男性青少年血清BAP、PICP和OC水平随年龄变化特点基本一致,高原藏族青少年高于平原汉族青少年。应进行大样本调查分析,建立针对高原藏族青少年的骨形成标志物的正常参考范围。
Objective To investigate the characteristics and differences of serum bone alkaline phosphatase (BAP), type Ⅰ procollagen carboxyterminal propeptide (PICP) and osteocalcin (OC) in adolescents of Lhasa, Nagqu and Jinzhou. To study the effects of adolescent growth and development Provide evidence. Methods A total of 746 healthy Tibetan male adolescents aged 12 to 18 years old in Lhasa and Naqu areas of Tibet and 343 male Han Chinese in Jinzhou plain were selected for determination of height, serum BAP, PICP and OC contents. Results Serum levels of BAP, PICP and OC in Lhasa and Naqu were higher than those in Jinzhou group, and there were significant differences between Lhasa group and Jinzhou group (P <0.01). The levels of three indexes in Lhasa group were significantly higher than those in Jinzhou group Nagqu group (P <0.01 or P <0.05). Serum BAP, PICP and OC peaked at 13-14 years old in Lhasa group, and peaked at 1 year earlier in Naqu and Jinzhou group. With age, the levels of all three biochemical markers were significantly decreased (P <0.05). Serum BAP, PICP and OC levels were closely related with height (r = 0.43,0.54,0.41, P <0.01). Conclusion Serum levels of BAP, PICP and OC in male adolescents at different altitudes are basically the same with age, while Tibetan adolescents in plateau are higher than plain adolescents in plain. Large sample surveys and analyzes should be conducted to establish the normal reference range for bone formation markers targeting Tibetan adolescents in the plateau.