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营养性巨幼细胞性贫血(简称NMA)是指由于叶酸和/或维生素B_(12)缺乏导致的DNA合成受阻,骨髓内出现大量巨幼变的一类贫血。国内外作者对该病骨髓中红系和粒系细胞的形态学改变做了许多观察和研究,然而对世核细胞的研究较为少见。因此我们对20例临床确诊的NMA患者骨髓巨核细胞进行了光镜观察,测量了巨核细胞的直径,并对其变化的发病机理进行了探讨。村料与方法 20例营养性巨幼细胞性贫血患者为我院近两年来诊治的病人,并用20例血液学正常者作为对照。
Nutritional megaloblastic anemia (NMA) refers to a class of anemia with a large number of megaloblastic disorders in the bone marrow that is obstructed by DNA synthesis due to a deficiency of folic acid and / or vitamin B 12. Domestic and foreign authors made a lot of observations and studies on the morphological changes of erythroid and granulosa cells in the bone marrow of the disease, however, the research on the nuclear cells is rare. Therefore, 20 cases of clinically diagnosed NMA patients with bone marrow megakaryocytes were observed by light microscopy, measuring the diameter of megakaryocytes, and the pathogenesis of its changes were discussed. Materials and Methods 20 cases of patients with nutritional megaloblastic anemia in our hospital for diagnosis and treatment of patients in the past two years, and 20 cases of normal hematology as a control.