论文部分内容阅读
舌癌发病率高且易向淋巴结转移 ,研究舌部淋巴管分布有助于了解舌癌的转移和预后 ,毛细淋巴管的形态学研究比较困难 ,毛细淋巴管内皮细胞在形态学上与毛细血管相似 ,常规染色在光镜水平难以区分 ,而淋巴管内皮细胞的核苷酸酶 (5 Nase)活性明显高于血管 ,在血管内皮细胞则具有高度活性的碱性磷酸酶 (Alpase) ,应用核苷酸酶 碱性磷酸酶双重染色法 ,可有效地显示舌部的淋巴管和毛细淋巴管的分布和走向。在肿瘤和正常组织交界区域的丝状乳头内含有丰富的毛细淋巴管 ,并与黏膜固有层内的毛细淋巴管汇合 ,结缔组织乳头内毛细淋巴管和黏膜固有层的毛细淋巴管 ,核苷酸酶活性有减低倾向。在肿瘤的中央部 ,结缔组织乳头及乳头内毛细淋巴管的分布 ,随上皮基底层形态的不规则变化而变化 ,且核苷酸酶活性显著下降 ,毛细淋巴管口径增大 ,舌部肿瘤组织周围的口径增大的新生淋巴管网 ,可能与舌癌易发生早期转移有关
The high incidence of tongue cancer and the tendency to lymph node metastasis, the study of tongue lymphatic distribution helps to understand the metastasis and prognosis of tongue cancer, capillary lymphatic morphological study more difficult, capillary lymphatic endothelial cells in morphology and capillary Similarly, conventional staining was indistinguishable at light microscopy, whereas 5 Nase activity of lymphatic endothelial cells was significantly higher than that of blood vessels and highly active alkaline phosphatase (Alpase) in vascular endothelial cells. The alkaline phosphatase double staining method can effectively display the distribution and direction of the lymphatic and lymphatic vessels in the tongue. In the tumor and normal tissue junction area of the filamentous nipple rich in lymphatic vessels, and with the lamina propria lymphatic capillary confluence, connective tissue papillary lymphatic capillaries and mucosal lamina propria of lymphatic capillaries, nucleotides Enzyme activity tends to decrease. In the central part of the tumor, the distribution of capillary lymphatic vessels in the connective tissue of the nipple and nipple changes with the irregular shape of the epithelial basal lamina, and the activity of nucleotidase is significantly decreased. The diameter of capillary lymphatic vessels is increased, and the tongue tumor tissue Around the caliber of nasopharyngeal increased network may be related to tongue cancer prone to early metastasis