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目的观察微量元素铬对糖尿病大鼠糖脂代谢的影响。方法选糖尿病大鼠经灌胃给予有机铬水溶液治疗12周后,分别观察口服有机铬200μg/d及400μg/d的糖尿病大鼠空腹血糖及血脂水平(血清总胆固醇、甘油三酯、低密度脂蛋白和高密度脂蛋白)。实验分为4组:1组为正常对照组;2组为铬200μg/d组;3组为铬400μg/d组;4组为糖尿病对照组。结果有机铬具有明显降低血糖、血清总胆固醇、低密度脂蛋白和甘油三酯及升高高密度脂蛋白的作用(P<0.05~P<0.01)。结论有机铬能明显改善糖尿病大鼠的糖脂代谢。
Objective To observe the effect of trace element chromium on glucose and lipid metabolism in diabetic rats. Methods The diabetic rats were given gavage with organic chromium aqueous solution for 12 weeks. The levels of fasting blood glucose and blood lipid (serum total cholesterol, triglyceride, low density lipoprotein (LDL)) in diabetic rats of 200 μg / d and 400 μg / Protein and high-density lipoprotein). The experiment was divided into 4 groups: 1 group as normal control group; 2 group as chromium 200μg / d group; 3 group as chromium 400μg / d group; 4 group as diabetes control group. Results Chromium had significant effects of reducing blood glucose, serum total cholesterol, LDL, triglycerides and increasing high density lipoprotein (P <0.05 ~ P <0.01). Conclusion Organic chromium can significantly improve the glucose and lipid metabolism in diabetic rats.