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目的：阐明人血丙种球蛋白（ＩＶＩＧ）治疗毛细支气管炎的新方法及其对患儿体液免疫功能的影响。方法：采用不同剂量人血丙种球蛋白治疗毛细支气管炎２０例，并作对照，应用单向免疫扩散法测定血清免疫球蛋白。结果：静脉注射人血丙种球蛋白可使患儿迅速退热和改善症状，从而缩短病程，减少并发症，疗效优于常规治疗组，且未见明显毒副作用；０．５ｇ／ｋｇ·ｄ组与０．２ｇ／ｋｇ·ｄ组疗效无明显差异，治疗后１周两组血清中ＩｇＧ均明显升高。结论：提示０．２ｇ／ｋｇ·ｄ治疗毛细支气管炎是一疗效好、相对经济的剂量。
Objective: To clarify the new method of treatment of bronchiolitis by human blood gamma globulin (IVIG) and its effect on humoral immune function in children. Methods: Twenty patients with bronchiolitis were treated with different dosages of human gamma globulin. The serum immunoglobulin was measured by one-way immunodiffusion. Results: Intravenous injection of human gamma globulin allowed the patient to rapidly withdraw fever and improve symptoms, thus shortening the course of disease and reducing the complication. The curative effect was better than that of conventional treatment group, and no obvious side effects were observed. 0.5g / kg · d Compared with 0.2g / kg · d group, there was no significant difference between the two groups. After 1 week of treatment, IgG in serum of both groups increased significantly. Conclusion: It suggests that 0.2g / kg · d treatment of bronchiolitis is a good and relatively effective dose.