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目的 :探讨99mTc TRODAT 1SPECT多巴胺转运体 (dopaminetransporter,DAT)显像对帕金森病 (Parkinson’sdisease ,PD)早期诊断的价值。方法 :对 7例早期PD患者、3例中晚期PD患者和 2例正常对照者行99mTc TRODAT 1SPECT脑断层显像 ,利用感兴趣区技术测定纹状体 /额叶 (striuatum/frontalcortex ,ST/FC)和纹状体 /枕叶 (striuatum/occipitalcortex ,ST/OC)的比值 ,表示纹状体的DAT活性。结果 :早期PD患者起病肢体对侧的ST/FC(1 10 6± 0 0 41)和ST/OC(1 12 3± 0 0 45 )比起病肢体同侧的ST/FC(1 2 47± 0 0 63 )和ST/OC(1 2 46± 0 0 3 4)明显降低 (两者P值均 <0 0 1)。早期PD患者起病肢体同侧的ST/FC和ST/OC比正常对照者显著降低 ,比中晚期PD患者起病肢体同侧的ST/FC和ST/OC显著增高。结论 :99mTc TRODAT 1脑SPECT显像有助于PD的早期诊断
Objective: To investigate the value of 99mTc TRODAT 1SPECT dopamine transporter (DAT) imaging in the early diagnosis of Parkinson’s disease (PD). Methods: 99m Tc TRODAT 1 SPECT brain imaging was performed in 7 patients with early PD, 3 patients with advanced PD and 2 normal controls. Striatum / frontal cortex (ST / FC ) And striatum / occipital cortex (ST / OC), indicating striatal DAT activity. Results: ST / FC (1 10 6 ± 0 0 41) and ST / OC (1 12 3 ± 0 0 45) contralateral to the onset limb in patients with early PD were significantly higher than those of ST / FC ± 0 0 63) and ST / OC (1 2 46 ± 0 0 3 4) were significantly lower (P <0.01 for both). The ST / FC and ST / OC of ipsilateral PD were significantly lower than those of the normal controls, which were significantly higher than that of the ipsilateral ST-FC and ST / OC of the patients with PD. Conclusion: 99mTc TRODAT 1 SPECT imaging is helpful for the early diagnosis of PD