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目的探讨泌乳素瘤患者血清泌乳素(PRL)水平升高的相关影响因素。方法泌乳素腺瘤61例,分析其术前泌乳素水平与年龄、性别、侵袭性、肿瘤大小、免疫组化PRL染色强度的关系。结果将所有病例按血清泌乳素水平分为≤100μg/L、>100μg/L两组,进行二项分类logistic回归分析,入选变量为年龄、侵袭性、免疫组织化学PRL染色强度,OR值分别为0.933、12.034和2.666。结论泌乳素腺瘤患者血清泌乳素水平与年龄、肿瘤侵袭性和免疫组织化学PRL染色强度有关,但压迫丘脑和垂体柄导致泌乳素释放抑制因子释放减少有可能参与影响了泌乳素的释放。
Objective To investigate the related factors of serum prolactin (PRL) levels in patients with prolactinoma. Methods 61 cases of prolactinoma, analysis of its preoperative prolactin levels and age, gender, invasiveness, tumor size, the relationship between the intensity of immunohistochemical staining of PRL. Results All cases were divided into two groups according to the level of serum prolactin ≤100μg / L and> 100μg / L. The binomial logistic regression analysis was used. The selected variables were age, invasiveness, immunohistochemical staining intensity of PRL, OR values were 0.933, 12.034 and 2.666. Conclusion Serum prolactin levels in patients with prolactinoma are related to age, tumor invasiveness and immunohistochemical staining intensity of PRL. However, the suppression of the release of prolactin releasing factor (PRP) caused by oppression of the thalamus and pituitary may have an impact on the release of prolactin.