论文部分内容阅读
目的 研究细胞间粘附分子１（ＩＣＡＭ１） 在葡萄膜炎免疫反应中的作用。 方法 应用免疫组织化学染色检查２０ 只正常眼和５４ 例葡萄膜炎眼球摘除眼的脉络膜和视网膜组织中ＩＣＡＭ１ 的表达。 结果 正常眼的脉络膜和视网膜组织没有ＩＣＡＭ１ 的阳性染色，葡萄膜炎眼中有增高表达（ Ｐ＜ ０ ．０１） ，外源性和内源性葡萄膜炎眼组间ＩＣＡＭ１ 表达统计学上无显著差异（ Ｐ＞ ０ ．０５） 。 结论 葡萄膜炎发病过程中，ＩＣＡＭ１ 介导白细胞和炎症部位组织细胞的识别和粘附，导致眼部组织的免疫性损伤
Objective To study the role of intercellular adhesion molecule-1 (ICAM-1) in the uveitis immune response. Methods Immunohistochemical staining was used to detect the expression of ICAM-1 in the choroid and retina of 20 normal eyes and 54 cases of uveitis. Results There was no ICAM-1 positive staining in the choroid and retina of normal eyes, and the expression of ICAM-1 in the eyes of uveitis and endogenous uveitis was increased (P <0.01) There was no significant difference (P> 0.05). Conclusion During the pathogenesis of uveitis, ICAM-1 mediates the recognition and adhesion of leukocytes and inflammatory cells in the tissues, resulting in the damage of the eye tissues