论文部分内容阅读
偏头痛与血小板聚集和血管舒缩功能障碍有关,而内皮素（ET）与这两者关系密切。本文观察了38例偏头痛患者在发作期和间歇期血浆ET水平变化,并探讨其临床意义,现报告如下。 对象和方法 一、对象: （一）头痛组。38例（男9,女29）,患者均来自门急诊,年龄13～50岁,平均37.5岁,平均病程4年。根据1988年国际头痛分类标准诊断。有先兆的偏头痛5例,无先兆的偏头痛33例。偏头痛发作期18例,间歇期20例、18例有家族史。所有病例头颅CT均无异常。发作期组,14例脑彩色多普勒（TCD）示脑血管痉挛,间歇期组6例TCD有脑血管痉挛。 （二）正常值由试剂盒提供。 二、标本采集及检测方法:发作组患者急诊从肘静脉采血2ml,间歇期组8Am空腹采血2ml,血液以EDTA-Na_2抗凝,内含50KIU抑肽酶制剂,血液抽取后置预冷的试管内,分离血浆,置-20℃保存待测。ET RIA kit由中国人民解放军总医院东亚免疫试剂研究所提供,按说明书操作。 三、统计学方法:全部结果用(?)±S表示,两样本均数的比较用t检验。
Migraine is associated with platelet aggregation and vasomotor dysfunction, whereas endothelin (ET) is associated with both. This article observed the 38 cases of migraine patients in the attack and intermittent changes in plasma ET levels, and explore its clinical significance, are as follows. Objects and methods First, the object: (a) headache group. 38 cases (male 9, female 29), patients were from emergency department, aged 13 to 50 years old, average 37.5 years, the average duration of 4 years. According to the 1988 International Headache Classification criteria diagnosis. 5 cases of migraine with aura, 33 cases of migraine without aura. Migraine attack in 18 cases, intermittent period in 20 cases, 18 cases had a family history. All cases of cranial CT were normal. In the attack group, 14 cases of cerebrovascular spasm showed cerebral color Doppler (TCD), and 6 cases of cerebral vascular spasm in intermittent group. (B) normal value provided by the kit. Second, specimen collection and detection methods: the onset group of patients with emergency blood from the elbow vein blood 2ml, intermittent group 8Am fasting blood 2ml, the blood EDTA-Na 2 anticoagulant, containing 50KIU aprotinin, blood extraction after pre-cooling test tube Within, separation of plasma, set at -20 ℃ to be tested. ET RIA kit by the Chinese People’s Liberation Army General Hospital East Asian Institute of Immunization reagents, according to instructions. Third, the statistical methods: All results (?) ± S said the two samples were compared using t test.