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女性,27岁,未婚。住院号276146。患者出生时面容、生长速度正常,于9岁起左额部逐渐增大隆起,生长发育较同年龄儿童明显为快,乳房发育,月经来潮。19岁起渐有头晕头胀;皮肤粗糙变厚、油脂多;手足增大,全身骨骼变粗;视力模糊、减退和复视;声音渐变粗哑,鼻音重;牙齿松动自行脱落一个;记忆力减退。近2年出现月经紊乱,半年来闭经。既往无其他病史。体检:血压110/70,身长172cm,体重90kg。皮肤粗糙增厚,毛孔粗,汗毛较粗长,无色素沉着斑。头颅大(枕额径41cm,枕颧径63cm),头发干枯,两侧面部不对称,左侧鼻、颧部明显隆起。左眼较右眼为高,左眼略突出,视力右眼0.3,左眼0.2。口唇周围有小须,两侧下颌骨宽大,下颏突出,上腭高耸,
Female, 27 years old, unmarried. Hospital number 276146. The face and growth rate of the patient were normal at the time of birth. From the age of 9 years, the left frontal part gradually increased and uplifted. The growth and development were significantly faster than those of the same age children, breast development, and menstrual cramps. From the age of 19, she gradually became dizzy and bulging; her skin was rough and thick, and her oils were thick; her hands and feet were enlarged and the whole body bones became thicker; her eyesight was blurred, diminished, and diplopia; her voice was coarse and dull, and her nasal sounds were heavy; she loosened her teeth and lost her memory; In the past 2 years, menstrual disorders have occurred and amenorrhea has been reported for six months. No other medical history. Physical examination: Blood pressure 110/70, length 172cm, weight 90kg. Rough skin, thick pores, coarse and long hair, no pigmentation spots. The head was large (41cm in frontal plane, 63cm in occipital orbital plane), dry hair, bilateral facial asymmetry, and prominent swelling of the left nose and ankle. The left eye is higher than the right eye, and the left eye is slightly prominent. The right eye has 0.3 eyesight and the left eye has 0.2 eyes. There are small whiskers around the lips, with large mandibles on both sides, prominent jaws, and high jaws.