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肿瘤细胞对化疗药物产生多药耐药（ＭＤＲ）是肿瘤化疗失败的主要原因。异搏定（ＶＰＬ）是最早被发现可逆转ＭＤＲ的化合物，但ＶＰＬ体外逆转ＭＤＲ所需浓度较高，因而限制了它在临床中应用。本实验选择ＶＰＬ和ＩＦＮ－α联合进行逆转，以观察二者是否有协同作用。材料...
Multidrug resistance of tumor cells to chemotherapeutic drugs (MDR) is the main reason for the failure of chemotherapy in tumors. Verapamil (VPL) was the earliest compound found to reverse MDR, but the high concentration of VPL needed to reverse MDR in vitro limits its usefulness in the clinic. The experiment chose VPL and IFN-α in combination to reverse, in order to observe whether the two synergies. material...