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目的探讨HPVL1壳蛋白在不同宫颈病变中的表达及其临床意义。方法采用免疫组化EnVi-sion法检测不同宫颈病变中HPVL1壳蛋白的表达。结果所有慢性宫颈炎和宫颈鳞状细胞癌中HPVL1壳蛋白均不表达。HPVL1壳蛋白在CIN1、CIN2和CIN3中的阳性表达率分别为79.5%、48.6%和3.1%,CIN2中HPVL1壳蛋白表达明显低于CIN1,CIN3明显低于CIN2,差异有统计学意义(P<0.01)。结论 HPVL1壳蛋白的检测可预测宫颈病变的发展趋势,尤其是对CIN1和CIN2的宫颈病变的治疗具有指导价值。
Objective To investigate the expression of HPVL1 capsid protein in different cervical lesions and its clinical significance. Methods Immunohistochemistry EnVi-sion method was used to detect the expression of HPVL1 capsid protein in different cervical lesions. Results All cases of chronic cervicitis and cervical squamous cell carcinoma did not express HPVL1 capsid protein. The positive expression rates of HPVL1 capsid protein in CIN1, CIN2 and CIN3 were 79.5%, 48.6% and 3.1% respectively. The expression of HPVL1 capsid protein in CIN2 was significantly lower than that in CIN1 and CIN3 was significantly lower than that in CIN2 (P < 0.01). Conclusion The detection of HPVL1 capsid protein can predict the development of cervical lesions, especially for the treatment of cervical lesions CIN1 and CIN2.