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软斑(Malacoplakia)是一种罕见的慢性炎性肉芽肿。早年认为系泌尿道特有,后发现人体几乎所有器官均可受累,如胃肠道、腹膜后、肺、骨、脑、皮肤、肾上腺、淋巴结、扁桃腺、结膜及生殖道等。好发于女性,约4倍于男子,但位于女性生殖器官者则甚罕见。1969年报道第一例,至1996年文献中仅30例左右。作者收集了其中的23例分析如下。 发病机理 不明,但现已公认与细菌感染有联系,最常见的致病菌是大肠杆菌。本文23例中12例实施了病变组织培养和尿培养,均分离出了大肠杆菌,其他致病菌有假单胞菌、克雷伯杆菌、葡萄球菌和分支杆菌等。患者自身素质常有异常,如免疫球蛋白缺乏,或有某些免疫抑制治疗史。
Malacoplakia is a rare chronic inflammatory granuloma. Early years that Department of urinary tract unique, and found that almost all organs of the human body can be involved, such as the gastrointestinal tract, retroperitoneal, lung, bone, brain, skin, adrenal gland, lymph nodes, tonsils, conjunctiva and genital tract. Occurs in women about 4 times that of men, but women who are female genital organs are rare. The first case was reported in 1969, up to only about 30 cases in the literature of 1996. The authors collected 23 of them as follows. The pathogenesis is unknown, but it is now recognized as being linked to bacterial infections, the most common of which is Escherichia coli. In this paper, 12 cases of 23 cases of pathological tissue culture and urine culture, were isolated from E. coli, other pathogens Pseudomonas, Klebsiella, Staphylococcus and mycobacteria and so on. Patients often have their own quality abnormalities, such as the lack of immunoglobulin, or some history of immunosuppressive therapy.