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目的:评价153钐-乙二胺四亚甲基磷酸(153Sm-EDTMP)联合唑来磷酸治疗前列腺癌骨转移的临床疗效及不良反应。方法:使用153Sm-EDTMP联合唑来磷酸静脉注射治疗20例去势后前列腺癌骨转移伴有不同程度骨痛患者,观察其镇痛效果、骨转移灶的变化及不良反应。结果:20例患者接受治疗后,止痛的总有效率94.12%,无效5.88%,骨转移灶有明显减少。所有患者均未发现严重的不良反应。结论:153Sm-EDTMP联合唑来磷酸对去势治疗后的前列腺癌骨转移骨痛的临床止痛疗效明显,对多发骨转移癌伴骨痛是一种有效的治疗方法。
OBJECTIVE: To evaluate the clinical efficacy and adverse reactions of samarium-ethylenediamine tetramethylene phosphate (153Sm-EDTMP) combined with zoledronic acid in the treatment of bone metastases of prostate cancer. Methods: Twenty patients with bone metastases of castrated prostate cancer were treated with 153Sm-EDTMP combined with zoledronic acid. The analgesic effects, changes of bone metastases and adverse reactions were observed. Results: After 20 patients received treatment, the total effective rate of analgesic was 94.12% and 5.88%, and the bone metastases were significantly reduced. No serious adverse reaction was found in all patients. Conclusion: 153Sm-EDTMP combined with zoledronic acid has obvious clinical curative effect on castrated bone metastasis of prostate cancer and is an effective treatment for multiple bone metastases with bone pain.