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1 5—氟脲嘧啶(5-Fu) 是常用的抗癌药。近年来用于急性胰腺炎(AP)的治疗,具有缓解腹痛及降低血、尿淀粉酶的作用.其机制是通过对胰腺腺泡的DNA和RNA合成的抑制.阻断胰腺外分泌细胞合成和分泌胰淀粉酶和胰蛋白酶。一般250～500 mg·d~(-1),静滴,连续5～7 d。由于其用量较小,一般不会产生明显的副作用。2 硝苯啶 为钙拮抗剂。用于AP的治疗,20 mg·次~(-1),tidpo,疗程5～7d,疗效明显优于常规疗法的对照组,尤其对腹痛的缓解更为迅速。作用机制是通过阻滞钙通道,使小动脉扩张,胰腺血流量增加,改善微循环,减轻胰腺水肿;并有抑制平滑肌收缩,缓解因胆道及胰管阻塞引起的腹痛,以及减少胰腺分泌的作用。
1 5-fluorouracil (5-Fu) is a commonly used anticancer drug. In recent years for the treatment of acute pancreatitis (AP), with the role of relieve abdominal pain and reduce blood, urine amylase, its mechanism is through the inhibition of pancreatic acinar DNA and RNA synthesis, blocking pancreatic exocrine cell synthesis and secretion Pancreatic amylase and trypsin. Generally 250 ~ 500 mg · d ~ (-1), intravenous infusion, continuous 5 ~ 7 d. Because of its smaller dosage, generally no obvious side effects. 2 nifedipine is a calcium antagonist. For the treatment of AP, 20 mg · times ~ (-1), tidpo, treatment of 5 ~ 7d, the effect was significantly better than the control group of conventional therapy, especially for the more rapid relief of abdominal pain. Mechanism is through the block of calcium channels, the arterioles dilated, pancreatic blood flow increased, improve microcirculation and reduce pancreatic edema; and inhibition of smooth muscle contraction, relieve biliary and pancreatic duct obstruction caused by abdominal pain, and reduce the role of pancreatic secretion .