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兔中性粒细胞（ＰＭＮ）表面有ＣＤ＿（１８）的基础表达，地塞米松（ＤＥＸ）可使其表达减少，并具有剂量依赖性；用糖皮质激素受体（ＧＲ）阻断剂ＲＵ３８４８６和ＤＥＸ同时处理ＰＭＮ，随着ＤＥＸ／ＲＵ３８４８６浓度比的下降，ＣＤ＿（１８）表达逐渐增加；单纯用ＲＵ３８４８６处理ＰＭＮ，对ＣＤ＿（１８）的表达无明显作用。本研究结果提示ＤＥＸ通过ＧＲ的介导，抑制了兔ＰＭＮＣＤ＿（１８）的表达。
The basic expression of CD 18 on the surface of rabbit neutrophil (PMN) was observed. Dexamethasone (DEX) reduced its expression in a dose - dependent manner. Glucocorticoid receptor (GR) blocker RU38486 and DEX treated PMN at the same time. With the decrease of DEX / RU38486 concentration, the expression of CD_ (18) gradually increased. Treatment of PMN with RU38486 alone had no effect on the expression of CD_ (18). Our results suggest that DEX inhibits the expression of PMNCD_ (18) in rabbits through the mediation of GR.