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目的 评估韶关市脊髓灰质炎 (脊灰 )强化免疫效果。方法 对韶关市 1 989～ 1 999年消灭脊灰活动资料进行统计分析。结果 该市 1 989年起十一次十九轮脊灰强化免疫共接种适龄儿童352 91 2 9人次 ,平均接种率为 96 86 % ,其中 1 991年起均达 96 0 0 %以上 ;同一出生队列的人群比较 ,各年份出生儿童后几轮实种人数均比第一轮增加 ;急性弛缓性麻痹病例 (AFP)中零剂次免疫人数逐年减少 ;4岁以下人群脊灰Ⅰ、Ⅱ、Ⅲ型中和抗体阳性率均由强化免疫前 ( 1 988年 )的 87 0 1 %、94 1 2 %、90 91 %升至强化免疫后期 ( 1 996年 )的 1 0 0 0 0 % ,GMRT由 6 0 71、72 57、4 3 50分别升至 1 94 0 1、1 37 1 9、1 0 3 97;脊灰发病率从 1 989年的 0 1 8/十万降至 1 991年的 0 0 7/十万 ,1 992年起无脊灰病例报告。 1 994～ 1 998年AFP监测中未发现脊灰野毒株感染病例。结论 韶关市多次脊灰强化免疫措施落实 ,有效阻断了脊灰野病毒的传播 ,对消灭脊灰的作用显著。
Objective To assess the effect of poliomyelitis (polio) enhancement in Shaoguan City. Methods The data of polio eradication activities from 1989 to 1999 in Shaoguan City were statistically analyzed. Results The city received eleven rounds of polio immunization with nineteen rounds of poliomyelitis from 1989 to 1991 with a total enrollment of 352,919 children, with an average vaccination rate of 96.86%, of which over 96 0% Compared with the cohorts, the number of births in each of the following years increased more than in the first round; the number of zero-dose immunization in AFP cases decreased year by year; the poliovirus I, II, III The positive rates of neutralizing antibodies were increased from 87 0 1%, 94 1 2% and 90 91% before intensified immunization (1988) to 100 000% at the late stage of intensified immunity (1 996 years). The GMRT was 6 0 71,72 57,4 3 50 rose to 1 94 0 1,1 37 1 9,1 0 3 97 respectively; the incidence of polio decreased from 0 1 8 per 100,000 in 1989 to 0 1 in 1991 0 7 / 100,000, no polio cases since 1992. From 1994 to 1988, no cases of poliovirus infection were found in AFP surveillance. Conclusion The implementation of multiple polio immunization measures in Shaoguan City effectively blocked the transmission of poliovirus and markedly eliminated the poliovirus.